artificial endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with depot gonadotropin releasing hormone agonist in women with regular menses.
نویسندگان
چکیده
objective: to investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (gnrh-a) in women with regular menses. amaterials and methods: this is a prospective randomized clinical trial conducted in two rt centers on 176 women undergoing frozen-thawed embryo transfer. all patients received oral estradiol valerate 4 mg daily from day 2 to day 5 and 6 mg per day from day 6 to the day of the pregnancy test. in day 13 of cycle, an ultrasound examination was performed. after ultrasound confirmation of endometrial thickness (≥8 mm) and no ovarian activity, progesterone in cyclogest supp (800 mg daily) was added. the dose of estradiol would be increased to 8 mg per day if the endometrial thickness was less than 8mm. two or 3 embryos were transferred via transcervical route 48 hours after the beginning of progesterone administration. in group a (93 patients), difereline (3.75 mg im), as a depot gnrh agonist was administered in the midluteal phase (day 21) of previous cycle. in the other group b (n = 83) steroid supplementation was commenced without prior pituitary suppression. chemical and clinical pregnancy rates were compared in two groups. results :no significant differences were seen between two groups in terms of chemical pregnancy and clinical pregnancy rates. conclusion: the findings support the artificial protocol without any pretreatment suppressive drugs to reduce the adverse side effects of gnrh agonists also to minimize the costs.
منابع مشابه
Artificial Endometrial Preparation for Frozen-Thawed Embryo Transfer with or without Pretreatment with Depot Gonadotropin Releasing Hormone Agonist in Women with Regular Menses
OBJECTIVE To investigate the reproductive outcome of artificial endometrial preparation with exogenous steroids for frozen-thawed embryo transfer with and without pre-treatment with depot gonadotropin releasing hormone agonist (GnRH-a) in women with regular menses. MATERIALS AND METHODS This is a prospective randomized clinical trial conducted in two ART centers on 176 women undergoing frozen...
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Background & aim: There are conflicting results regarding the benefit of gonadotropin releasing hormone (GnRH) agonist treatment on frozen embryo transfer (FET) outcome. No study was found to compare pregnancy outcome between patients undergoing short and long acting types of GnRH agonist for FET cycles. This study aimed to assess the effectiveness of short and long ac...
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OBJECTIVE To determine the preferred regimen for women with adenomyosis undergoing in vitro fertilization (IVF), we compared the IVF outcomes of fresh embryo transfer (ET) cycles with or without gonadotropin-releasing hormone (GnRH) agonist pretreatment and of frozen-thawed embryo transfer (FET) cycles following GnRH agonist treatment. METHODS This retrospective study included 241 IVF cycles ...
متن کاملMethods for endometrial preparation in frozen-thawed embryo transfer cycles.
Frozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization- intracytoplasmic sperm injection cycles. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred have led to a progressive increase in FT embryo transfer cycles. However, the best solution for endo...
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OBJECTIVE This study aims to evaluate the effectiveness of GnRH agonist in comparison with hCG for triggering final oocyte maturation in endometrial preparation of letrozole stimulation protocols for frozen-thawed embryo transfer. METHODS The frozen-thawed embryo transfer cycles (FET) that use the letrozole stimulation protocols for endometrial preparation were divided into two groups accordi...
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Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are report...
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عنوان ژورنال:
journal of family and reproductive healthجلد ۹، شماره ۱، صفحات ۱-۴
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